I usually have the camera set as follows:
Ap or manual
ISO - whatever the situation calls for but use a tripod and get the ISO down if possible
white balance - hardly ever shoot for a custom white balance, but I will choose one of the custom settings (i.e. tungsten, etc...) if situation calls for it. AWB works very well, especially outdoors
metering - center weighted, unless subject is lit differently than environment
focus - one shot, unless activity requires ai servo - never the middle one
continuous - whatever dictates - 5fps is wonderful
I shoot RAW only - no JPEG - I can save all the JPEGS I want after batch processing in ACR
Custom functions - aside from default, I set the second curtain preference on flash and that's about it.
You will love it. I have about 10,000 clicks and not a problem.