I have read several reports that claim that the F4 IS version is the sharperst, by a very slim, probably-doesn't-matter margin.
That said I recenlty swapped that for its big brother, the F2.8 IS primarily because I wanted to use either the 1.4X or 2X TC...or both, without losing out on AF.
I think all iterations of that lens is superior in IQ...can't go wrong whichever one you go with!

