Since money doesn't seem to be much of an issue, I'd say get the f/2.8. You said you don't want to second-guess yourself about the lens again and this is your second chance. I originally got the f/4 non IS and wasn't entirely satisfied in my decision until I just recently got the f/2.8 IS. While I don't see myself needing the IS on a regular basis, I will be needing it from time to time and I'm more satisfied with the lens by having it and not needing it 100% of the time than I would be if I needed it and didn't have it.
I don't know if there's a weight difference between the f/2.8 non IS and IS, but there's definitely a difference between the f/4 and f/2.8. I've walked around for 8-10 hours before (at an amusement park) with the f/4 and it didn't really bother me, but I could see the f/2.8 becoming an issue for longer periods. Personally, though, I would leave size and weight out of the equation when figuring up pros/cons