When I first bought my 100-400, I hated that lens for the dust issues. I had more problems with dust and it on my 5D than any combo I'd ever owned...and said so on POTN several times...
HOWEVER, over time, I realized a few things....the 5D is the dustiest camera I've ever owned, it just seems to gather dust and I've learned to live with it's foibles...(but not knowing about that didn't help the 100-400's review any)...
After several serious cleanings/rocket blowings of the 5D, I noticed a few things...the first being that I could use the 100-400 as much as I ever did with no noticeable dust accumulation.
The 100-400 DOES move the air a lot more in the camera chamber...Ollie did a test on here somewhere where it shows just how it can inflate/deflate a plastic bag, and the other types of zooms cannot do this...
So, my re-vamped opinion of the 100-400 is that while it does move the dust already in the camera, I don't think it necc. sucks in any dust into itself or the camera.
(btw, I'm still not a big fan of the lens, but am trying to give an honest evaluation of it's pluses and minuses...)
The way it is designed; their are gaskets to prevent the dust from going into the lens or camera.I imagine if a gasket cracked or dried out then you may have some problems.

) It was a sandwich bag...
