I use the 3800. I find it very simple to use. The sheet feeder works flawlessly, which is a big deal to me cuz my last printer wouldn't feed correctly.
The switch on and ready to print is approximately 45 seconds.
I haven't had to replace an ink cartridge yet, but it should be very easy to do.
Print driver is easy to navigate. I usually use Lightroom for print control so I don't utilize the Epson driver.
The printer takes up significant floor space, but it is a sight to behold. 
Ink consumption: it is difficult to estimate, but I can tell you that I have almost consumed a box of 50 8.5x11 sheets of Epson paper, and I've taxed the ink about 10%. I've also printed on 4x6 Epson, and the printer handles the paper as efficiently as the 8.5 x11.
I haven't printed my 13x19 paper yet, but I don't expect any issues doing so.
Connection: I use USB 2.0, but I could use Ethernet if I had more than one computer printing photos.
I bought the printer in May or 2007.
I'm very happy with the 3800.
Hope that helps.