I think I saw in a DO lens cross section that there is only one DO element in the 400/4DO lens. I think it just replaces a UD lens.
We all use DO lenses, there is one on every flash gun, either built in or external. Some even use a second in the form of a better beamer or something. This simple DO lens is the well known freshnel lens. Only a mm thick or so, and it acts like a much larger spherical lens.
To really appreciate the pros and cons of a DO lens construction, one would need an all-DO or at least most-DO lens design. It is most certain that such an all-DO lens design could give a 1200/4 or 1200/5.6 lens weighing less than 4 pounds (if the barel was made of plastic). Weight and cost should be a benefit, because DO lenses are pressed and this is a much cheaper construction method.
The fact that the 400/4DO lens is not very well received (with only one DO element) means that an all-DO lens would not deliver all that good IQ.
If I could see a future in DO optics, it would be in low cost, ultra compact and thin cameras. And yet, we see these cigarette box sized cameras using 3 element extended barels for mounting normal glass or plastic spherical lenses. Some Canon high end cameras even utilize UD and aspherical elements to achieve apochromatism, which is the main benefit of DO lenses.
I just think that since Canon can afford to have two lenses in their lineup that don't sell, and since they made research in this area, they just brought out the most descent incarnation of their efforts if only to say: Hey, we also do DO lenses.