Something doesn't add up with the picture posted in the first post. The EXIF data is...
ISO = 100 - there shouldn't really be any noise unless massively underexposed and then boosted in PP.
FL = 188mm
Tv = 1/320
Av = f/4.0
EC = +2.0 !!!!!!!!!!
The shutter speed is fast enough (1/320) to suggest camera shake is not an issue with a 188mm focal length. But why is the EV set to +2.0? There is nothing in the image posted to explain the need for +2.0 EC yet the picture is not overexposed. So it seems we are looking at a cropped image, sized to 800*533. The questions are....
- Was the image cropped to exactly 800*533 before being output from Photoshop, or was it possibly cropped to something less and then inadvertently upsized to 800*533, leading to the poor IQ?
- What does the whole, original, uncropped image look like?
- Are we actually seeing a crop from the part of the image that was supposed to have been focused?
- Maybe the camera to subject distance did change between setting focus and taking the shot, but only the OP can know. Since I don't believe we are seeing the full original picture and the IQ is shot to pieces it is hard to know what was going on.
- Was this shot in raw and then processed to a cropped/resized jpeg or was this shot in jpeg to begin with?
- If shot in jpeg to begin with, what were the camera settings (picture style, sharpness etc.?)
- What processing was performed in Photoshop?
Maybe some more background from the OP or a reshot/reprocessed picture might help. Either way, at 100 ISO I don't really see that noise should be the issue for discussion here.
EDIT : By the way, the colour space setting for the jpeg is Adobe RGB. It should be sRGB for the web.