Imagenomic Noiseware does a fantastic job on my ISO 1600 pictures from my 30D. I'm not afraid to use a high ISO anymore to harness normally beautiful ambient light. As a side benefit, the program also does a great job on smoothing skin. Here is a picture of my 5-month old daughter at ISO 1600 and I think you can see what I mean. Great software! Pretty cute, isn't she? Chip off the old block! 

