there are no issues with this. They can be very well padded in most situations. I travelled with a 17" flatscreen monitor, mini tower desktop, keyboard, mouse, cords, external hard drive, and 2 lenses all in a large suitcase padded with some clothes.
I had a couple flights like this, and transfers of baggage in between. The only real issue is theft. You can't lock a suitcase on most airlines nowadays, and i have heard people talk about thefts from luggage. They also have a right to random search your luggage, and may not "repack" your stuff as nicely as you would have. it is a chance you take for national security.
Make sure you are lucky, or insured.
Mike