I redo the factory settings. One with +2 contrast, one with -2 contrast, and one with saturation +1. Neutral and faithful I don't touch. The rest I do monochrome. +/- 2 contrast, then add in orange and red filters.
Most of my shots are good to go if I get the exposure right. I try not to mess around too much with post processing, unless I'm trying to do something funky or totally save a blown shot (i.e. being sloppy, shooting without tripod, etc.).
Check my gallery, especially the Zion Color and Black White and Antelope Canyon stuff to see what straight out of the camera can do for you. Of course a good CPL does wonders too.
I can see how someone could get real creative in photoshop/lightroom etc. and do some amazing things. It's almost too much for me though and the style I'm after.