Ken,
Personally if I am only using one flash on camera indoor my first choice is to bounce off a neutral colored wall with no diffuser. In this case the wall IS the diffuser. By bouncing it off a wall it converts my small harsh light source into a large diffuse light source. No sense in adding a diffusser on top of the bounce. It will only serve to eat up more flash power. The next priority would be for me to bounce off the ceiling, again, with no diffuser. But, that being said I WOULD use a bounce card. I have one built in to my 580EX flash that I pull up when bouncing. I do this because you do want to throw some 'extra' light forward to help fill some of the shadow areas you may still get from a bounce flash. For example when bouncing off the ceiling most of the light is now going to be coming down from above and falling on the subject which can cause shadows in the eye sockets, not good, racoon face. But, using the bounce card throws just enough forward to fill those shadows to make it look better.
My last choice is to use a diffuser with no bounce and only use that method when there is nothing to bounce off.
Of course if i am shooting a wedding reception and know that the place has no where to bounce I will bring extra flashes on stands and use those.