While I love my Pelican 1514 and my Think Tank Airport Addicted has flown more than 300,000 miles (or around there), depending on your needs I just started using the Mountainsmith Correspondent bag. In to months I tool this bag around the world and schlepped it to assignments on three continents and found out I loved it!
The Mountainsmith Correspondent, unlike the Think Tank rollers, has an internal slot of a laptop (up to 17"), a large front pocket you can use for clothes if you choose not to use it for papers, laptop,magazine, etc, and a unique interior you can set up for gear, or 1/2 gear & 1/2 clothes for quick trips, etc.
I detailed the Correspondent, with text and photos, on my site for flying photogs, Flying With Fish
. You can read the entry at:
http://flyingwithfish.blogspot.com …respondent-versatile.html
......at 200,000+ miles flown per year shooting photo assignments and projects (and around 1,000,000 miles since 2005 , when I started paying attention to my miles) the Correspondent is the most versatile roller I have used. It's not for photogs who use big glass (I have a separate case for my 400f2.8 ), but for general use it is fantastic!
ETA: You can pack a 300f2.8 if you do it properly & 300f4 / 400f5.6 lenses are no problem for those who worry about slower long glass.