It really depends on what you are shooting, how long you can hold the camera still (whether in hand or, better, if you have a tripod), and how much noise you can personally stand in your images prior to post production. For example, I shoot landscapes mostly and spend most of my time at low ISO setting (the 30D only goes down to 100
), but I am also using a tripod much of the time and am using mid to high F# and longer exposures to maximize depth of field.
Recently, my tripod was stolen, so I have had to do everything handheld (which is really annoying after using a tripod for so long). So now, I use a lower F# and a higher ISO setting to get a exposure that is not too long for my hand to hold still and still get decent sharpness in my pictures. In reality, it's all give and take.
Best of luck.
John