I can load everything in my sig into a lowepro naturetrekker ii and walk all day. It has an adjustable waist to top of the straps velcro thingy that works incredibly well.
If you are carrying a fair amount of weight; get a backpack with waist straps. Go to REI and tell them you're thinking about backpacking for the first time and ask them about backpack fitting.
They will tell you most of the weight actually sits on your hips and NOT on your shoulders.
This should help you a LOT.



