I just finished my first shoot with my new 50D. I shot about 300 pics, Changed 3 different brand lenses (Canon, Tamron and Tokina) several times, WITH the power on, and NEVER got an ERR99! 
From all the naysayers in here, it sounded like I should have just sent it back, still in the box, and bought an XSi...
But seriously... I'm no pro, I just play one while the girls are looking.
I sold my 40D to upgrade to this model and I have to say that I really enjoyed shooting it tonight. The camera performed flawlessly, the new screen was greatly appreciated by myself and the models as they checked their work. I have not had time to sit down to edit yet, but at a quick glance, they look good in lightroom 2.1.
For those of you still anxiously waiting to get your 50D's, and reading all the bad news on here about your new purchase. Fear not. It is possible to get a good one. Like someone said. You don't normally hear about the people that got perfect ones, because they are out shooting!
And for those that got a model that acted up... don't worry. With a little patience all will be made right. I've never heard of Canon releasing a new model, having trouble in the field, and just leaving it.
I credit tonights success to proper break-in procedures. At 6:15 p.m. mountain time, I fired the first shots at some very handsome ducks...8 p.m. sharp found me taking aim at an experienced model, and the rest of the night went swimmingly.
YMMV.
Regards, -Todd-
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