Clark wrote in post #6914488
Ok, I know there are lots of threads already. I can't seem to find anything about which way to go if your lens is front or back focusing.
IE: front focus you use + settings, back focus you use - settings, or doesn't it work that way?
I will be getting to use my new 50D today and was just going to mess with the MA.
Mmmm, I wouldn't 'mess' with it unless you need to 
From memory the '-' will 'pull back' the point of focus toward you, so if you are front focusing you will need the '+' to 'push' the point of focus away from you - Hope that makes sense.
.......of course I may have that the wrong way round...

Easiest way is to 'play' with one lens and see what happens. But as i say, unless you think one of your lenses has a problem I'd leave alone.
I had to adjust my 70-200 Sigma a fair bit (-6), and my 24-105L by a whisker (+1).