I voted yes. The lens is at it's softest wide open at 400mm, you will get greater sharpness by stopping down of course, just as with pretty much any lens.
Equally, like most zooms it doesn't match the sharpness from the best primes.
However, the key point (for me) is that it is still sharp enough to give great results. Here's a 100% crop from a shot of a fox, taken at 400mm, wide open at f/5.6, straight from the camera apart from RAW to jpeg conversion. Pixel peeping at this size shows slight softness, however once PP'd, sharpened and viewed at normal size the images are plenty sharp enough.
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