the OP never stated that he uses Canon's wireless system. If his gear list in the signature is true to the letter, he has only one 580 EX II.
AFAIK, if the 580EXII is set to master, it will perform a Master's job without knowing whether there are any slaves within communication range.
For example, a windowlight shot may need the background lifting. Put a 580EXII on-camera as Master, with the main flash OFF. In the background, set a 550EX on the ministand, as Group C. Set the Master A:B C ratios to anything.
In this case, the preflash exposure tests from Group A and Group B will tell the camera that there are no such flashes; it does not test-fire Group C. As far as the camera knows, there are no flashes (if indeed it bothers to deduce that). However, when the shutter has opened, the master will still emit a "Fire!" coding and the Group C flash fires.
So, I conclude that if you have set an on-camera flash as master, it will behave as such, regardless.

