I was listening to a pro photographer last night who does a lot of travelling, and he quite clearly stated that prolonged vibration of a camera, such as a long trip along a rough mountain road, in a backpack when riding/hiking .... well you can get the sort off scenario he was refering to, will cause the IS to fail (the gyros etc to lock up/fail) and that you should only take prime lenses on these sorts of trips.
I would have though that with the camera turned off there would be no power to the IS mechanism and as such it wouldn't be suspect to damage.
Curious as to others thoughts and experiences, as I am very careful with my gear, but I have my 5D Mk II + 24-105 with me every day in the car etc 


