Stacked 2x and 1.4x reduces the amount of light three stops. So yes you can try to compensate either by ISO or shutter speed from just the plain lens, you just have to decide which is least detrimental.
The advantage of using a mirrorless camera is shooting with 'lighting effects on'. The image in the viewfinder is exactly how the captured image will look and adjusting shutter speed for example immediately shows the scene getting brighter or dimmer in manual mode. Another advantage of the 61mp sensor on the Sony a7r4 is that in crop mode, the resolution is still 26mp. I have a button assigned to toggle APS-C mode on and off.






