E-TTL II requires that you have a flash mounted on-camera, or on a compliant off-camera E-TTL cord. The camera asks the flash to emit a low-power pre-flash so that the camera can determine the difference between an ambient exposure reading and the flashed exposure reading. The required settings are then given to the flash, and it is told to fire. It is the camera which determines the exposure required, in accordance with your settings on both camera and flash.
For Canon Wireless, a second E-TTL-compliant flash is required as Master, or a 7D camera body, or the latest Pocket Wizards. RadioPoppers require two flashes to provide the coding stream.
Simple radio triggers cannot handle the complex E-TTL communications between camera and flash.
Pixel have the promise of E-TTL at a mid-price, and do not require a Master flash, but they are overdue for releasing the TR-332. Read first assessments when they are published, before buying.