When I started building my kit I decided I wanted to be able to carry everything with me in on back pack. I carry my 50D, 17-40, 70-200-2.8, 400-5.6, and 60mm-ef-s macro, a super-light and affordable Slik tripod as well as a speedlite and a bunch of accessories in a Tamrac Expedition 5X. My whole kit ways almost exactly 25lbs. Hiking is as important as photography to me and I can still do about 15 miles in a day trip with all of my gear. Depending on your physical condition, this may not be the way to go for everybody, but it works for me. I am prepared for almost every situation I could be interested in.
One more benefit... Since my pack is stuffed, I can't buy anything new unless I part with something else. This helps me resist stupid temptations. Anyway, I don't foresee buying anything new as I think my kit meets my needs almost perfectly.