I recently went to Vietnam via Singapore Airlines and I had the Pelican StudioCruzer (1510 w/compartment MBP)
The reason I chose Pelican over the Think Tank is because it's weather sealed and it's a hardcase. Yeah, it's heavier but who cares. It has wheels. Rolled my Pelican around in Frankfurt, Singapore, and Vietnam. No problems whatsoever.
At first I was like oh ****. This case already weights in at 14 lbs unloaded. After I packed my lenses, body, and MBP, it was at around 32lbs. Keep in mind, this is my carry on.
I thought it was going to be a problem at the airport but to my surprise, they were more then willing to let me board w/the Pelican despite it's weight. They one guy (manager?) he asked if I was carrying camera equipment and I said yes...then he said, ok no problem, just go on ahead.
Being as to how legit the Pelican cases look, I got stopped at nearly all the security check points...just for a swap but that's it. No other problems. Without the wheels, I wouldn't have been able to bring the case around at all.