^^^ tough crowd!
The FoV of a 100mm, especially on a crop sensor, is going to give you a pretty tight window. You can do it, but it wouldn't be my first choice for the type of foreground/background juxtaposition that (I think) you're talking about. The shot below was taken with a FF (5D) - the buildings are well in to the background and the pylons in the (relative) foreground are still pretty far away from my position.
Looking at Hyperfocal calculators, your "foreground" will have to be at least 55 feet away at f/16 to maintain focus on the mountains, as well. Again, you can do it, and with spectacular results, but you'll be counting on mother nature to line up your shots and give you a place to stand.
