I used to use Neat Image Pro until CS5 came out. With that said, I almost never use any NR since I moved to a 5DII. I find I can print ISO3200 shots up to 24 inches wide with no noise showing. Probably larger but I haven't tried. If I need any NR, the built in NR in ACR is very good, imo. For web, I see no reason to use NR from 5DII files.
Sharpening... I have never gotten a good handle on sharpening web sized images for Smugmug. Too much detail gets blown away when you resize a 5DII image down to 700 pixels on the long side. Flickr adds their own sharpening and they seem to do a pretty good job.
I have tried Photokit Sharpener and I liked the results, for web. The trial ended before I had a chance to send anything out for printing but on my monitor it looked like it did things quite intelligently. I'm going to try and get another trial, if possible. Nik Sharpener. I've never been completely happy with what it does. You get hue shifts and it's heavy handed, imo, even if you play around with the settings. So, as far as sharpening, I am the last person that can help you 